The Gan Lab

About the PI

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Team (hiring now!)

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Publications

After independence: (2025-present):

1. Wang Z, Gan P*. Enhancer Dynamics for Gene Regulation in the Cardiovascular System. Arterioscler Thromb Vasc Biol. 2026 Jan 8. ( *corresponding author)
2. Gan P*, Zhou X, Shah AM, Bezprozvannaya S, Chen K, Ding Q, Li H, Xu L, Liu N, Olson EN*. Engineering a serum response factor superactivator of smooth muscle gene expression with a condensate-forming domain. PNAS. 2025 Sep 15. ( *co-corresponding author)

Before independence (2015-2025):

1. Caravia XM, Hayashi B, Li H, Gan P, Alzhanov D, Tan W, Chen K, McAnally J, Xu L, Liu N, Olson EN. Precise gene editing of pathogenic Lamin A mutations corrects cardiac disease. PNAS. 2025 Oct 13.
2. Garry G, Dos Santos M, Chen K, Tan W, Bezprozvannaya S, Gan P, Xu L, Liu N, Bassel-Duby R, Olson EN. Cellular reprogramming by PHF7 enhances cardiac function following injury. Circulation. 2025 Jul 9.
3. Ding Q, Gan P, Xu Z, Li H, Guo L, MacDonald C, Tan W, Sanchez-Ortiz E, McAnally J, Zhang Y, Karri D, Xu L, Liu N* & Olson EN*. Genomic Editing of a Pathogenic Mutation in ACTA2 Rescues Multisystemic Smooth Muscle Dysfunction Syndrome in Mice. Circulation. 2025 May 16. ( *co-corresponding author)
4. Gan P^#, Eppert M^#, De La Cruz N, Lyons H, Shah AM, Veettil RT, Chen K, Pradhan, P, Bezprozvannaya S, Xu L, Liu N, Olson EN* & Sabari BR*. Coactivator Condensation Drives Cardiovascular Cell Lineage Specification. Science Advances. 2024 Mar 15;10(11):eadk7160. (#co-first author, *co-corresponding author)
5. Gan P, Wang Z, Bezprozvannaya S, McAnally J, Tan W, Li H, Bassel-Duby R, Liu N, Olson EN. RBPMS Regulates Cardiomyocyte Contraction and Cardiac Function through RNA Alternative Splicing. Cardiovascular Research. 2024 Feb 27;120(1):56-68. 
6. Watanabe H, Tao G, Gan P, Westbury B, Cox K, Tjen K, Song R, Fishman G, Makita K, Sucov HM. Purkinje Cardiomyocytes of the Adult Ventricular Conduction System Are Highly Diploid but Not Uniquely Regenerative. J. Cardiovasc. Dev. Dis. 2023 April 7; 2023, 10(4), 161.
7. Sodimu O, Almasian M, Gan P, Hassan S, Zhang X, Bassel-Duby R, Liu N, Ding Y. Light-Sheet Imaging and Interactive Analysis of the Cardiac Structure in Neonatal Mice. Journal of Biophotonics. 2023 Jan 9;e202200278.
8. Caravia XM, Martinez AR, Gan P, Wang F, McAnally J, Xu L, Bassel-Duby R, Liu N, Olson EN. Loss of Function of the Nuclear Envelope Protein LEMD2 Causes DNA Damage-dependent Cardiomyopathy. Journal of Clinical Investigation. 2022;132(22):e158897.
9. Gan P, Wang Z, Morales MG, Zhang Y, Bassel-Duby R, Liu N, Olson EN. RBPMS is an RNA-Binding Protein that Mediates Cardiomyocyte Binucleation and Cardiovascular Development. Developmental Cell. 2022 Apr 25;57(8):959-973.e7. 
10. Gan P, Baicu C, Watanabe H, Wang K, Tao G, Judge DP, Zile MR, Makita T, Mukherjee R, Sucov HM. The Prevalent I686T Human Variant and Loss of Function Mutations in the Cardiomyocyte-specific Kinase Gene TNNI3K Cause Adverse Contractility and Concentric Remodeling in Mice. Human Molecular Genetics. 2020 Oct 21:ddaa234.
11. Gan P, Patterson M, Watanabe H, Wang K, Edmonds RA, Reinholdt LG, Sucov HM. Allelic Variants between Mouse Substrains BALB/cJ and BALB/cByJ Influence Mononuclear Cardiomyocyte Composition and Cardiomyocyte Nuclear Ploidy. Scientific Reports. 2020 May 5;10(1):7605.
12. Shen H, Gan P, Wang K, Darehzereshki A, Wang K, Kumar SR, Lien CL, Patterson M, Tao G, Sucov HM. Mononuclear Diploid Cardiomyocytes Support Neonatal Mouse Heart Regeneration in Response to Paracrine IGF2 Signaling. Elife. 2020 Mar 13; 9: e53071.
13. Gan P, Patterson M, Velasquez A, Wang K, Tian D, Windle J, Tao G, Judge D, Makita T, Park TJ, Sucov HM. Tnni3k Alleles Influence Ventricular Mononuclear Cardiomyocyte Frequency. PLoS Genetics. 2019 Oct 7;15(10): e1008354.
14. Gan P, Patterson M, Sucov HM. Cardiomyocyte Polyploidy and Implications for Heart Regeneration. Annual Review of Physiology. 2019 Oct 4. Vol. 82. (Review)
15. Wang K, Shen H, Gan P, Cavallero S, Kumar SR, Lien CL, Sucov HM. Differential Roles of Insulin Like Growth Factor 1 Receptor and Insulin Receptor during Embryonic Heart Development. BMC Developmental Biology. 2019 Mar 25;19(1):5.
16. Patterson M, Barske L, van Handel B, Rau CD, Gan P, Sharma A, Parikh S, Denholtz M, Huang Y, Yamaguchi Y, Shen H, Allayee H, Crump JC, Force TI, Lien CL, Makita T, Lusis AJ, Kumar SR, Sucov HM. Frequency of Mononuclear Diploid Cardiomyocytes Underlies Natural Variation in Heart Regeneration. Nature Genetics. 2017 Sep;49(9):1346-1353. 

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